Dupuytren's (du-pwe-TRANZ) Contracture is a hand deformity that generally develops over several years. The disease affects a layer of tissue that lies under the skin of your hand creating a thick cord that can pull one or more fingers into a bent position. The fourth and fifth digits (ring finger and the pinky), are the most commonly affected. But any of the fingers may be involved, including the thumb. The fingers bend towards the hand and cannot be completely stretched out.